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AGE DEPENDENCY of the SUSCEPTIBILITY of RATS TO AMINOOXYACETIC ACID SEIZURES
(Elsevier B.V., 1992-06-19)
Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. Highest susceptibility to AOAA seizures was observed in 7-14-day-old rat pups. the lowest susceptibility ...
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry
(Elsevier Science Inc, 2018-06)
Background: Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used. Therefore, we aimed to compare the occurrence of major congenital malformations ...
Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
(ELSEVIER SCIENCE BV, 2011)
To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects ...
Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2006)
Addressing overtreatment in patients with refractory epilepsy at a tertiary referral centre in Brazil
(JOHN LIBBEY EUROTEXT LTD, 2011)
Background. Patients with refractory epilepsy often have impaired quality of life (QOL) as a consequence of seizures and adverse effects of antiepileptic drugs. We assessed the impact of adverse effects on QOL and the ...
3D-QSAR design of novel antiepileptic sulfamides
(Pergamon-Elsevier Science Ltd, 2007-02-01)
A three-dimensional quantitative structure-activity relationship method, the comparative molecular field analysis (CoMFA), was applied to design new anticonvulsant symmetric sulfamides. The training set (27 structures) was ...
Network pharmacology and epilepsy
(Springer, 2016)
In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...
Acute psychotic disorders induced by topiramate - Report of two cases
(Assoc Arquivos De Neuro- PsiquiatriaSao Paulo SpBrasil, 2002)