Artículos de revistas
Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
Fecha
2011Registro en:
EPILEPSY RESEARCH, v.94, n.1/Fev, p.117-120, 2011
0920-1211
10.1016/j.eplepsyres.2011.01.007
Autor
FREITAS-LIMA, Priscila
ALEXANDRE JR., Veriano
PEREIRA, Leonardo Regis Leira
FELETTI, Fausto
PERUCCA, Emilio
SAKAMOTO, Americo Ceiki
Institución
Resumen
To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p = 0.01) and a shorter half-life (p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients. (C) 2011 Elsevier B.V. All rights reserved.