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Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
(Elsevier, 2013-03)
Background: New evidence suggests that different β2-adrenergic receptor (β2AR) polymorphisms may influence asthma control in patients receiving long-acting β2-agonists (LABAs) as regular therapy.
Objectives: To determine ...
β2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
(2010)
Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
The influence of adrenergic blockade in rats with apical periodontitis under chronic stress conditions
(2020-02-01)
Objective: To investigate the influence of chronic stress and adrenergic blockade in a rat model of apical periodontitis. Methods: Thirty-two Wistar rats were submitted to an animal model of periapical lesion and randomly ...
Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of α1A-adrenergic receptors
(2017-12-01)
In LNCaP cells that stably express α1A-adrenergic receptors, oxymetazoline increased intracellular calcium and receptor phosphorylation, however, this agonist was a weak partial agonist, as compared to noradrenaline, for ...
2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity
(MDPI, 2017-03)
The beta(3) adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and ...
Ovarian steroidal response to gonadotropins and β-Adrenergic stimulation is enhanced in polycystic ovary syndrome: Role of sympathetic innervation
(1993)
Experimental induction of a polycystic ovarian syndrome (PCOS) in rodents by the administration of a single dose of estradiol valerate (EV) results in activation of the peripheral sympathetic neurons that innervate the ...
The β1 adrenergic effects of antibodies against the C-terminal end of the ribosomal P2β protein of Trypanosoma cruzi associate with a specific pattern of epitope recognition
(Wiley Blackwell Publishing, Inc, 2005-10)
BALB/c mice immunized with recombinant Trypanosoma cruzi ribosomal P2β protein (TcP2β) develop a strong and specific antibody response against its 13 residue-long C-terminal epitope (peptide R13: EEEDDDMGFGLFD) that has a ...
Alpha 1 adrenergic receptor-mediated inflammatory responses in human testicular peritubular cells
(Elsevier Ireland, 2018-10-15)
Stress activates the sympathetic nervous system and is linked to impaired fertility in man. We hypothesized that catecholamines by acting on testicular cells have a role in these events, possibly by fostering an inflammatory ...