Buscar
Mostrando ítems 451-460 de 819
Neurons born in the adult dentate gyrus form functional synapses with target cells
(Nature Publishing Group, 2008)
Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and ...
Expression of vesicular glutamate transporters in sensory and autonomic neurons innervating the mouse urinary bladder
(Elsevier, 2013-07)
Purpose: Vesicular glutamate transporters (VGLUTs), essential for loading glutamate into synaptic vesicles, are present in various neuronal systems. However, the expression of VGLUTs in neurons innervating the urinary ...
Ontogenetic oligodendrocyte maturation through gestational iron deprivation: The road not taken
(Wiley-liss, div John Wiley & Sons Inc., 2019-09)
Developmental iron deficiency (dID) models facilitate the study of specific oligodendrocyte (OL) requirements for their progression to a mature state and subsequent contribution to myelination. In the current work, we used ...
Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells
(OMICS International, 2016-04)
The goal of magnetic field-assisted gene transfer is to enhance internalization of exogenous nucleic acids by association with magnetic nanoparticles (MNPs). This technique named magnetofection is particularly useful in ...
Redistribution of the intra-acrosomal EGFP before acrosomal exocytosis in mouse spermatozoa
(Bioscientifica, 2015-05)
Mammalian spermatozoa must undergo complex physiological and morphological alterations within the female reproductive tract before they become fertilization competent. Two important alterations are capacitation and the ...
Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropes
(Endocrine Society, 2011-05)
Arachidonic acid (AA) is generated in the anterior pituitary gland upon stimulation by the ACTH secretagogue, CRH. Using the patch clamp technique, we examined the action of AA on the excitability of single pituitary ...
Knocking down of diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat
(American Physiological Society, 2007-05-01)
We recently showed that diencephalic TRH may mediate the central leptin-induced pressor effect. Here, to study the role of TRH in obesity-induced hypertension (OIH), we used a model of OIH produced by a high-fat diet (HFD, ...
Suicide HSVtk Gene Delivery by Neurotensin-Polyplex Nanoparticles via the Bloodstream and GCV Treatment Specifically Inhibit the Growth of Human MDA-MB-231 Triple Negative Breast Cancer Tumors Xenografted in Athymic Mice
(Public Library of Science, 2014)
The human breast adenocarcinoma cell line MDA-MB-231 has the triple-negative breast cancer (TNBC) phenotype, which is an aggressive subtype with no specific treatment. MDA-MB-231 cells express neurotensin receptor type 1 ...
Role of thymulin on the somatotropic axis in vivo
(Pergamon-Elsevier Science Ltd, 2012-09)
Aims: There is clear evidence for the existence of a bi-directional thymus-somatotropic axis and several studies suggest that the thymic peptide thymulin may be involved in this communication. We undertook to assess the ...
Restorative effect of intracerebroventricular insulin-like growth factor-I gene therapy on motor performance in aging rats
(Pergamon-Elsevier Science Ltd, 2011-03-17)
Insulin-like growth factor-I (IGF-I) is a powerful neuroprotective molecule in the brain and spinal cord. We have previously shown that intracerebroventricular (i.c.v.) IGF-I gene therapy is an effective strategy to increase ...