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Mostrando ítems 31-40 de 90
Padronização da técnica de qPCR para quantificação do comprimento relativo telomérico no Caenorhabditis elegans
(Universidade Federal de Minas GeraisUFMG, 2016-07-22)
Telomeres have a fundamental role in cellular replication and through their length it is possible to estimate cellular life span mean. Evidence has shown that factors such as environmental, social, nutritional and ...
The relationship of telomere length to baseline corticosterone levels in nestlings of an altricial passerine bird in natural populations.
(2016)
Background: Environmental stressors increase the secretion of glucocorticoids that in turn can shorten telomeres via oxidative damage. Modification of telomere length, as a result of adversity faced early in life, can ...
Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies
(Oxford University Press, 2018)
© 2018 American Society for Nutrition. Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the ...
Absolute qPCR for Measuring Telomere Length in Bone Marrow Samples of Plasma Cell Disorders
(Humana Press, 2015-02)
Telomere length (TL) is currently used as an emerging biomarker in understanding the development/progression of hematological malignancies. The absolute quantitative PCR (qPCR) methodology has allowed the study of TL from ...
Analysis of telomere length in mantle cell lymphoma
(Wiley Blackwell Publishing, Inc, 2009-11)
Mantle cell lymphoma (MCL) is a well defined lymphoid neoplasm genetically characterized by the t(11;14)(q13;q32). Telomeres play an essential role in preserving chromosomal integrity and genomic stability; their shortening ...
Desenvolvimento de um biomarcador molecular baseado no comprimento de telômeros em peixes da espécie Rhamdia quelen (ordem siluriforme)
(Universidade Tecnológica Federal do ParanáDois VizinhosBrasilLicenciatura em Ciências BiológicasUTFPR, 2021-12-10)
In recent decades, the National Council for Control of Animal Experimentation (CONCEA) has aimed to establish the 3Rs guideline: Replace, Reduce, and Refine. In this context, there is a need to adapt ecotoxicological tests ...
TRF1 as a major contributor for telomeres’ shortening in the context of obesity
(Free Radical Biology And Medicine, 2018)
Telomerase as a cancer target. Development of new molecules
(Cell Press, 2002-10)
Telomeres are the terminal part of the chromosome containing a long repetitive and non-codifying sequence that has as function protecting the chromosomes. In normal cells, telomeres lost part of such repetitive sequence ...
Gravity and Telomeres
(Austin Publishing Group, 2018-08)
Telomere shortening is a well-known process that is proposed to influence the pace of aging in every living being. On the other hand, telomere lengthening seems to be restricted to pluripotent cells and adult stem cell ...