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Heparan sulfate-binding peptide promotes the deposition of proteoglycans in the extracellular matrix
(Wiley-Blackwell, 1997-06-15)
A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn el al. (1996): Arch Biochem Biophys 325:129-138], has now been found to promote ...
Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
(2020-11-25)
Plant peptide protease inhibitors are important molecules in seed storage metabolism and to fight insect pests. Commonly they contain multiple disulfide bonds and are exceptionally stable molecules. In this study, a novel ...
Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
(Portland Press, 2004-06-15)
The kininogenase activities of mouse (mK1), rat (rK1) and human (hK1) tissue kallikrems were assayed with the bradykinin-containing synthetic peptides NH2-MTEMARRPPGFSPFRSVTVQ-NH2 (where Abz stands for o-aminobenzoyl) and ...
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012-08-01)
Toxin-antitoxin (TA) proteic systems encode a toxin and an antitoxin that regulate the growth and death of bacterial cells under various stress conditions. The ParE protein is a toxin that inhibits DNA gyrase activity and ...
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012-08-01)
Toxin-antitoxin (TA) proteic systems encode a toxin and an antitoxin that regulate the growth and death of bacterial cells under various stress conditions. The ParE protein is a toxin that inhibits DNA gyrase activity and ...
Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β 42 monomer
(Academic Press Inc Elsevier Science, 2018-12)
A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ 42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ 42 aggregation as ...
Bioactive peptides in human milk: a systematic review
(Universidade Federal de São Paulo, 2023-04-25)
Objectives: Identify peptides and biological activity in human milk (HM).
Methodology: A systematic review was conducted in the MEDLINE, LILACS,
Cochrane, Embase) and from the gray literature (Google Scholar) ...
Integrin inhibitors from snake venom: Exploring the relationship between the structure and activity of RGD-peptides
(Elsevier B.V., 2009-02-01)
alpha IIb beta 3 is ail integrin that is involved in platelet adhesion and aggregation. This receptor may be inhibited by cysteine-rich peptides known as disintegrins. We isolated two disintegrins from Bothrops jararaca ...
Acetylcholinesterase inhibitory activity of a naturally occurring peptide isolated from Boana pulchella (Anura: Hylidae) and its analogs
(Springer, 2020-03)
Alzheimer’s disease (AD), the most common form of dementia, is a growing problem worldwide, with 10 million incident cases registered every year. The complex etiology of AD has not been clarified yet and represents an ...