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Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis
(ELSEVIER SCIENCE INC, 2011)
Objective: MicroRNAs (miRNAs) are small noncoding regulatory RNAs (19-25 nucleotides) that play a major role in regulation of gene expression. They are responsible for the control of fundamental cellular processes that has ...
Dinâmica de redes genéticas regulatórias do destino celular em resposta a dano ao dna contemplando senescência, autofagia e apoptose
(Universidade Federal de Santa MariaBrasilFísicaUFSMPrograma de Pós-Graduação em FísicaCentro de Ciências Naturais e Exatas, 2021-03-24)
How a cell determines a given phenotype upon damaged DNA is an open problem. Cell
fate decisions happen at cell cycle checkpoints and it is becoming clearer that the p53
pathway is a major regulator of cell fate decisions ...
Citrus psorosis virus 24K protein interacts with citrus miRNA precursors, affects their processing and subsequent miRNA accumulation and target expression
(Wiley Blackwell Publishing, Inc, 2015-05)
Sweet orange (Citrus sinensis), one of the most important fruit crops worldwide, may suffer from disease symptoms induced by virus infections, thus resulting in dramatic economic losses. Here we show that the infection of ...
Perfil de expressão diferencial de miR-34a em Glioblastoma Multiforme
(Universidade Estadual Paulista (Unesp), 2020-02-20)
Os tumores do Sistema Nervoso Central (SNC), embora considerados raros, contribuem de forma significativa para a morbidade e mortalidade mundial. Dentre os tumores do SNC, o glioblastoma multiforme (GBM) apresenta o pior ...
Long 3'UTR of Nurr1 mRNAs is targeted by miRNAs in mesencephalic dopamine neurons
(2017)
The development of mesencephalic dopamine neurons and their survival later in life requires the continuous presence of the transcription factor Nurr1 (NR4A2). Nurr1 belongs to the nuclear receptors superfamily. However, ...
Deciphering the role of miR-71 in echinococcus multilocularis early development in vitro
(Public Library of Science, 2019-12)
Echinococcosis represents a major public health problem worldwide and is considered a neglected disease by the World Health Organization. The etiological agents are Echinococcus tapeworms, which display elaborate developmental ...
Papel do miR-23b e miR-133a no controle de expressão de componentes da via TRAIL de apoptose em células de adenocarcinoma de pulmão (A549) e carcinoma renal (CaKi-2) e na sensibilização de células A549 ao TRAIL
(Universidade Federal de São Paulo, 2023-04-18)
Introdução: A despeito dos avanços nas terapias antineoplásicas, desenvolvimento
de resistência tumoral é um dos principais desafios no tratamento do câncer. A via de
apoptose desencadeada pelo TRAIL é potencial alvo ...
ΔNp63α suppresses cells invasion by downregulating PKCγ/Rac1 signaling through miR-320a
(Nature Publishing Group, 2019-09)
ΔNp63α, a member of the p53 family of transcription factors, is overexpressed in a number of cancers and plays a role in proliferation, differentiation, migration, and invasion. ΔNp63α has been shown to regulate several ...
Repression of Cell Proliferation by miR319-Regulated TCP4
(Oxford University Press, 2014-07)
Leaf development has been extensively studied on a genetic level. However, little is known about the interplay between the developmental regulators and the cell cycle machinery—a link that ultimately affects leaf form and ...