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Mostrando ítems 31-40 de 97
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease.
Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits. These abnormalities ...
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model
(2018)
We have previously reported that primary hippocampal neurons exposed to synaptotoxic amyloid beta oligomers (A beta Os), which are likely causative agents of Alzheimer's disease (AD), exhibit abnormal Ca2+ signals, ...
Late onset temporal lobe epilepsy with MRI evidence of mesial temporal sclerosis following acute neurocysticercosis: case reportEpilepsia de lobo temporal de início tardio com evidências de esclerose mesial temporal após quadro agudo de neurocisticercose: relato de caso
(Academia Brasileira de Neurologia - ABNEURO, 2001)
Neuroimaging Evidence Of Progressive Neuronal Loss And Dysfunction In Temporal Lobe Epilepsy
(Lippincott Williams and Wilkins, 1999)
IRE1 signaling exacerbates Alzheimer's disease pathogenesis
(Springer, 2017)
Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy
(2018)
Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2C transients, which are ...
Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer
(Springer, 2018-11)
The specific roles of Notch in progressive adulthood neurodegenerative disorders have begun to be unraveled in recent years. A number of independent studies have shown significant increases of Notch expression in brains ...
Adult Neurogenesis Is Altered by GABAergic Imbalance in Models of Alzheimer's Disease
(Cell Press, 2009-12)
Early stages of Alzheimer's disease (AD) affect hippocampal function. In this issue of Cell Stem Cell, Li et al. (2009) and Sun et al. (2009) propose abnormal GABA signaling as a trigger for impaired network plasticity in ...
APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
(Elsevier Science Inc, 2018-04-20)
Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the direct involvement of APP in the ...