Artículos de revistas
Neuroimaging Evidence Of Progressive Neuronal Loss And Dysfunction In Temporal Lobe Epilepsy
Registro en:
Annals Of Neurology. Lippincott Williams And Wilkins, v. 45, n. 5, p. 568 - 576, 1999.
3645134
10.1002/1531-8249(199905)45:5<568::AID-ANA4>3.0.CO;2-P
2-s2.0-0032933248
Autor
Tasch E.
Cendes F.
Li L.M.
Dubeau F.
Andermann F.
Arnold D.L.
Institución
Resumen
Whether temporal lobe epilepsy is the result of an isolated, early injury or whether there is ongoing neuronal dysfunction or loss due to seizures is often debated. We attempt to address this issue by using magnetic resonance techniques. Proton magnetic resonance spectroscopic imaging can detect and quantify focal neuronal dysfunction or loss based on reduced signals from the neuronal marker N-acetylaspartate (NAA), and magnetic resonance imaging (MRI)-based measurements of hippocampal volumes (MRIvol) can quantify the amount of atrophy in this structure. We performed magnetic resonance spectroscopic imaging and MRIvol in 82 consecutive patients with medically intractable temporal lobe epilepsy to determine whether there was a correlation between seizure frequency, or type or duration of epilepsy, with NAA to creatine (Cr) values or hippocampal volumes. Volumes and spectroscopic resonance intensities were categorized as to whether they were measured from the temporal lobe ipsilateral or contralateral to the predominant electroencephalographic focus. Ipsilateral and contralateral NAA/Cr was negatively correlated with duration of epilepsy. Hippocampal volumes were negatively correlated with duration ipsilaterally but not contralaterally. Frequency of complex partial seizures was not correlated with any of the magnetic resonance measures. However, patients with frequent generalized tonic-clonic seizures had lower NAA/Cr bilaterally and smaller hippocampal volumes ipsilaterally than patients with none or rare generalized tonic- clonic seizures. 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