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Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
(ELSEVIER SCIENCE BV, 2011)
To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects ...
Bioactive molecule-loaded drug delivery systems to optimize bone tissue repair
(2017-08-01)
Bioactive molecules such as peptides and proteins can optimize the repair of bone tissue; however, the results are often unpredictable when administered alone, owing to their short biological half-life and instability. ...
Monoclonal antibodies carried in drug delivery nanosystems as a strategy for cancer treatment
(2021-01-01)
Monoclonal antibodies carried in nanosystems have been extensively studied and reported as a promising tool for the treatment of various types of cancers. Monoclonal antibodies have great advantages for the treatment of ...
Rebound acid hypersecretion after withdrawal of gastric acid suppressing drugs: new evidence of similitude
(ELSEVIER SCI LTD, 2011)
Background: Homeopathy is based on the principle of similitude (similia similibus curentur) using medicines that cause effects similar to the symptoms of disease in order to stimulate the reaction of the organism. Such ...
Enterohepatic Recycling
(Springer Nature Switzerland AG, 2021)
Broadly speaking, enterohepatic recycling (or enterohepaticcirculation) involves the circulation of metabolized and non-metabolizedcompounds (including physiologic compounds and xenobiotics) between theintestine and the ...
Improving temozolomide biopharmaceutical properties in glioblastoma multiforme (GBM) treatment using GBM-targeting nanocarriers
(2021-11-01)
Glioblastoma multiforme (GBM) is the most common primary brain cancer. GBM has aggressive development, and the pharmacological treatment remains a challenge due to GBM anatomical characteristics’ (the blood–brain barrier ...
Farmacocinética das estatinas
(Sociedade Brasileira de Cardiologia - SBC, 2005-10-01)
Statins are lipid lowering agents that promote their effects on plasma lipids through the inhibition of HMG-CoA reductase, a crucial enzyme in the cascade of cholesterol synthesis, leading to reduction of tissue cholesterol ...