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Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma
(2016-06-01)
The purpose of this study was to evaluate the expression of the enzymes involved in the biotransformation of tobacco and alcohol. A study group of 41 young patients (≤40 years old) with oral squamous cell carcinoma (OSCC) ...
A Comparative Study of CYP3A4 Polymorphisms in Mexican Amerindian and Mestizo Populations
(Pharmacology, 2007-06-15)
Cytochrome P-450 3A4 (CYP3A4) contributes to the metabolism
of approximately half the drugs in clinical use today. The
aim of the present study was to determine the frequency of
the CYP3A4 * 1B , * 2 , * 4 , * 5 , and ...
Modulation of Cytochrome P450 2A5 Activity by Lipopolysaccharide: Low-Dose Effects and Non-Monotonic Dose-Response Relationship
(Public Library of Science, 2016)
Study of the allelic variants CYP2C9*2 and CYP2C9*3 in the Peruvian mestizo population Estudio de las variantes alélicas CYP2C9*2 y CYP2C9*3 en población mestiza peruana
(Instituto Nacional de Salud, 2019)
Introduction: CYP2C9 metabolizes approximately 15% of the prescribed drugs. Its gene has alleles whose frequencies differ between ethnic groups and populations. The alleles CYP2C9*2 and CYP2C9*3, account for an enzyme with ...
Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450cam (CYP101A1)
(Academic Press Ltd - Elsevier Science Ltd, 2018-04)
Cytochrome P450cam (CYP101A1) catalyzes the stereospecific 5-exo hydroxylation of d-camphor by molecular oxygen. Previously, residual dipolar couplings measured for backbone amide 1H–15N correlations in both substrate-free ...
Roles of cytochromes P450 in plant reproductive development
(U B C Press, 2021-01)
The cytochrome P450 superfamily is a large enzymatic protein family that is widely distributed along diverse kingdoms. In plants, cytochrome P450 monooxygenases (CYPs) participate in a vast array of pathways leading to the ...
Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population
(Penerbit Universiti Sains, 2015)
Elección del mejor antidepresivo en pacientes con cáncer de mama en tratamiento con tamoxifeno: revisión de la evidencia básica y clínica
(Sociedad Médica de Santiago, 2016)
Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed ...