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Prevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study.
(Elsevier Science, 2017-10)
Since the decline in new cases of infection by insect/vector, congenital Chagas disease has become more relevant in the transmission of Chagas disease. Treatment with benznidazole significantly reduces the parasitemia, ...
Benznidazole levels in blood vary with age in rats
(Fundacao Oswaldo Cruz, 2011-05)
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this ...
Benznidazole treatmentof Chagasic encephalitis in pregnant women with AIDS
(Centers Disease Control, 2013-09)
We report a case of chagasic meningoencephalitis reactivation in a pregnant woman co-infected with Trypanosoma cruzi and HIV that was successfully managed with benznidazole and highly active antiretroviral therapy. Early ...
Suspensión pediátrica de Benznidazol para el tratamiento de la enfermedad de Chagas
(Sociedad Iberoamericana de Información Científica, 2015-10)
La falta de medicamentos aptos para atender a pacientes pediátricos infectados con Chagas, motivó el desarrollo de una suspensión, conteniendo benznidazol, a partir de los comprimidos comerciales, garantizando su calidad. ...
Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
(Fundação Oswaldo Cruz, 2008-09)
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats ...
In vitro studies and preclinical evaluation of benznidazole microparticles in the acute Trypanosoma cruzi murine model
(Cambridge University Press, 2020-12)
Chagas disease is a serious parasitic infection caused by Trypanosoma cruzi. Unfortunately, the current chaemotherapeutic tools are not enough to combat the infection. The aim of this study was to evaluate the trypanocidal ...
Potenciais formulações com o benznidazol para tratamento de crianças com doença de Chagas
(Universidade Federal de Pernambuco, 2014)