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Study of nuclear decondensation of the rat spermatozoa by reducing agents during epididymal transit
(1994)
Summary. Chromatin packing, mostly due to disulfide bond formation, is one important step in epididymal sperm maturation. In this study the in vitro effect of a reducing agent such as thioglycolate (Tg) was tested. ...
Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression
(Amer Assoc Advancement Science, 2016)
Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition ...