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HPV16 E6 regulates annexin 1 (ANXA1) protein expression in cervical carcinoma cell lines
(Elsevier B.V., 2016-09-01)
Annexin 1 (ANXA1) is a substrate for E6AP mediated ubiquitylation. It has been hypothesized that HPV 16 E6 protein redirects E6AP away from ANXA1, increasing its stability and possibly contributing to viral pathogenesis. ...
20S proteasome activity is modified via S-glutathionylation based on intracellular redox status of the yeast Saccharomyces cerevisiae: Implications for the degradation of oxidized proteins
(Elsevier B.V., 2014-09-01)
Protein S-glutathionylation is a post-translational modification that controls many cellular pathways. Recently, we demonstrated that the alpha 5-subunit of the 20S proteasome is S-glutathionylated in yeast cells grown to ...
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
(Nature Publishing Group, 2014-03)
Tumour metastasis is the primary cause of mortality in cancer patients and remains the key challenge for cancer therapy. New therapeutic approaches to block inhibitory pathways of the immune system have renewed hopes for ...
Plant Strategies To Control Growth And Development: Integration Of Both Signal Molecules, Auxin And Nitric Oxide
(Plos, 2018-08)
The term auxin is derived from the Greek word ?auxein,? which means to grow or to expand and 3 was sealed by Charles Darwin more than a century ago. In ?The Power of Movement in Plants? 4 (1880), Darwin first described the ...
Epigenetic regulation of the ribosomal cistron seasonally modulates enrichment of H2A.Z and H2A.Zub in response to different environmental inputs in carp (Cyprinus carpio)
(BMC, 2013-07)
Background: The specific deposition of histone variants into chromatin is an important epigenetic mechanism that contributes to gene regulation through chromatin architectural changes. The histone variant H2A.Z is essential ...
Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus
(Public Library of ScienceFacultad de Ciencias Básicas y Biomédicas, 2019)
The aim of this study was to identity in silico the relationships among microRNAs (miRNAs)
and genes encoding transcription factors, ubiquitylation, DNA methylation, and histone
modifications in systemic lupus erythematosus ...
Progressive myoclonic epilepsy type 8 due to CERS1 deficiency: a novel mutation with prominent ataxia
(Movement Disorders Clinical Practice, 2023)