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Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans
(NATURE PUBLISHING GROUP, 2008)
The adenovirus type 5 (Ad5)-based vaccine developed by Merck failed to either prevent HIV-1 infection or suppress viral load in subsequently infected subjects in the STEP human Phase 2b efficacy trial. Analogous vaccines ...
Inmunoterapia con las vacunas de ADN en la infección experimental con Trypanosoma cruzi en Macacos rhesus
(25/10/2010)
ABSTRACT: Trypanosomiasis Americana represents a primary health issue in the Americas. The World Health
Organization (WHO) estimates that around 9 million people are infected with Trypanosoma cruzi.
For the control of ...
Contribution of the murine and primate models to the study of arenaviral diseases and hemorrhagic feversContribución de los modelos murino y primate al estudio de las enfermedades por arenavirus y fiebres hemorrágicas
(Universidad de Antioquia, Facultad de Ciencias AgrariasCENTAUROMedellín, Colombia, 2017)
Zika virus congenital syndrome: experimental models and clinical aspects
(BioMed Central, 2017)
Abstract
Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, ...
A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques
(Oxford University Press, 2014-03)
STUDY QUESTION
Can administration of a prostaglandin (PG) E2 receptor 2 (PTGER2) antagonist prevent pregnancy in adult female monkeys by blocking periovulatory events in the follicle without altering menstrual cyclicity ...
Membrane vesicles released by intestinal epithelial cells infected with rotavirus inhibit T-cell function
Rotavirus (RV) predominantly replicates in intestinal epithelial cells (IEC), and 'danger signals' released by these cells may modulate viral immunity. We have recently shown that human model IEC (Caco-2 cells) infected ...
Does infection of 2019 novel coronavirus cause acute and/or chronic sialadenitis?
2019 novel coronavirus (2019-nCoV) is widespread in China and other countries. The target of 2019-nCoV and
severe acute respiratory syndrome coronavirus (SARS-CoV) is angiotensin-converting enzyme 2 (ACE2) positive
cells. ...
A computational model for the modulation of the prepulseinhibition of the acoustic startle reflex
(Springer, 2012)
The acoustic startle reflex (ASR), a defensiveresponse, is a contraction of the skeletal and facial musclesin response to an abrupt, intense (>80 db) auditory stimu-lus, which has been extensively studied in rats and ...