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In vitro evaluation of leptin fragments activity on the ob receptor
(Wiley-Blackwell, 2008-05-01)
In an attempt to identify regions in the leptin molecule responsible for its bioactivity, we tested six related-leptin peptide fragments denoted: Ae-hLEP(23-47)-NH(2) (I), Ac-hLEP(48-71)-NH(2) (II), Ac-hLEP(72-88)-NH(2) ...
Leptin and IGF1 receptors in alpaca (Vicugna pacos) ovaries
(Elsevier Science, 2019-01)
Folliculogenesis and ovulation are regulated by gonadotrophins and other factors such as Insulin like growth factor 1 (IGF1) and leptin. In various species the presence of IGF1 receptor (IGF1R) and leptin receptor (ObR) ...
Association between feeding behavior, and genetic polymorphism of leptin and its receptor in obese chilean children Asociación entre la conducta alimentaria y polimorfismos genéticos de la leptina y su receptor en niños obesos chilenos
(Grupo Aula Medica S.A., 2015)
© 2015, Grupo Aula Medica S.A. All rights reserved. Introduction: Leptin (LEP) is mainly produced in adipose tissue and acts in the hypothalamus to regulate energy intake. Mutations in the LEP gene or its receptor (LEPR) ...
Sistema leptina-melanocortinas en la regulación de la ingesta y el peso corporal
(2009)
Obesity is a multifactorial disease that is rarely associated to single gene defects. However, due to their direct cause-effect relationships, those genetic defects that cause some forms of monogenic obesity are relevant ...
Association of single nucleotide polymorphisms in the bovine leptin and leptin receptor genes with growth and ultrasound carcass traits in Nellore cattle
(FUNPEC-EDITORARIBEIRAO PRETO, 2012)
Given the important role of leptin in metabolism, we looked for a possible association of leptin and leptin receptor polymorphisms with carcass and growth traits in Nellore cattle. We examined associations of leptin and ...
Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers
(Revista Española de Nutrición Humana y Dietética, 2018)
Leptin receptor expression in mammary gland of lactating and no lactating cowsExpresión de receptores de leptina en glándula mamaria de bovinos lactantes y no lactantes
(Universidad de Ciencias Aplicadas y Ambientales U.D.C.A, 2015)
Role of G-proteins in the effects of leptin on pedunculopontine nucleus neurons
(Wiley, 2013-06)
The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system, regulates waking and rapid eye movement sleep. Here, we demonstrate immunohistochemical labeling of the leptin receptor signaling ...
Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas
(BioScientifica, 2013-04)
Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated ...
Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity
(Pergamon-Elsevier B.V. Ltd, 2011-06-06)
Aims: Leptin resistance has been associated with cardiac lipotoxicity; however, whether leptin resistance is a risk factor associated with cardiac lipotoxicity at different time points in diet-induced obesity is unclear. ...