Artículo de revista
Association between feeding behavior, and genetic polymorphism of leptin and its receptor in obese chilean children Asociación entre la conducta alimentaria y polimorfismos genéticos de la leptina y su receptor en niños obesos chilenos
Fecha
2015Registro en:
Nutricion Hospitalaria, Volumen 31, Issue 3, 2018, Pages 1044-1051
16995198
02121611
10.3305/nh.2015.31.3.8049
Autor
Vega, Macarena Valladares
Obregón, Ana María
Weisstaub, Gerardo
Burrows, Raquel
Patiño, Ana
Ho-Urriola, Judith
Santos, José Luis
Institución
Resumen
© 2015, Grupo Aula Medica S.A. All rights reserved. Introduction: Leptin (LEP) is mainly produced in adipose tissue and acts in the hypothalamus to regulate energy intake. Mutations in the LEP gene or its receptor (LEPR) that produce monogenic obesity are infrequent. However, LEP and LEPR polymorphisms have been associated with obesity multifactorial, due to the association found with body weight and eating behavior. Aim: Measure the association between LEP and LEPR polymorphisms with childhood obesity and eating behavior. Methods: 221 Chilean obese children (BMI above the 95th percentile) were recruited. Parents of 134 of these children were also recruited to determine the association between LEP and LEPR polymorphisms with obesity in a case study-parent trio. Eating behavior was measured through the questionnaire of three factors progenitors’ version (TFEQ-P19) and eating behavior in children (CEBQ). Results: No significant difference between the studied polymorphisms and childhood o