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Protein and mRNA content of TcDHH1-containing mRNPs in Trypanosoma cruzi
(CIENCIAS, 2010)
In trypanosomatids, the regulation of gene expression occurs mainly at the post-transcriptional level. Previous studies have revealed nontranslated mRNA in the Trypanosoma cruzi cytoplasm. Previously, we have identified ...
Processing bodies oscillate in neuro 2A cells
(Frontiers Media S.A., 2019-10)
Circadian rhythms are biological variables that oscillate with periods close to 24 h that are generated internally by biological clocks. Depending on the tissue/cell type, about 5–20% of genes are expressed rhythmically. ...
PKA isoforms coordinate mRNA fate during nutrient starvation
(Company of Biologists, 2012-08)
A variety of stress conditions induce mRNA and protein aggregation into mRNA silencing foci, but the signalling pathways mediating these responses are still elusive. Previously we demonstrated that PKA catalytic isoforms ...
Caracterização da ribonucleoproteína RBP42 no parasito Trypanosoma cruzi sob condições de estresse
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2019-02-25)
RNA binding proteins (RBPs) are essential components for gene expression regulation. The interaction between RBPs and target mRNAs forms ribonucleoprotein complexes that dictate RNA fate and may aggregate into microscopically ...
Cyclin T1 overexpression induces malignant transformation and tumor growth
(Landes Bioscience, 2010)
Human PTEFb is a protein kinase composed by CDK9 and Cyclin T that controls the elongation phase of RNA Pol II. This complex also affects the activation and differentiation program of lymphoid cells. In this study we found ...
Redistribución nuclear de ARN polimerasa II iniciadora y TCF7L2 por efecto de la vía de señalización WNT/ß-catenina en células KG-1
(Universidad Andrés Bello, 2017)
La hematopoyesis es el proceso de formación, desarrollo y maduración de células sanguíneas y es regulada por distintas vías de señalización, entre ellas: la vía de señalización Wnt/β-catenina. Sin embargo, cuando se producen ...
MCL-1 is modulated in Crohn’s disease fibrosis by miR-29b via IL-6 and IL-8
(Springer, 2017-05)
The miR-29 family is involved in fibrosis in multiple organs, including the intestine where miR-29b facilitates TGF-β-mediated up-regulation of collagen in mucosal fibroblasts from Crohn’s disease (CD) patients. Myeloid ...
Cellular Promyelocytic Leukemia Protein Is an Important Dengue Virus Restriction Factor
(Public Library Of Science, 2015-05)
The intrinsic antiviral defense is based on cellular restriction factors that are constitutively expressed and, thus, active even before a pathogen enters the cell. The promyelocytic leukemia (PML) nuclear bodies (NBs) are ...
A exonuclease XRNA e o metabolismo de mRNA em Trypanosoma cruzi
(2015)
A regulação da expressão gênica em tripanossomatídeos ocorre majoritariamente pelo controle de eventos pós-transcricionais. Dentre estes, mudanças na estabilidade e acesso dos mRNAs à maquinaria de tradução estão diretamente ...
Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice
(2020)
Background: Hexanucleotide repeat expansions of the G4C2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues ...