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Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity
(Elsevier Ireland, 2009-12)
It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional regulation is not described yet. In this study we analyzed the relationship ...
Structural determinants of the interaction between influenza a virus matrix protein M1 and lipid membranes
(Elsevier Science, 2019-03)
Influenza A virus is a pathogen responsible for severe seasonal epidemics threatening human and animal populations every year. One of the ten proteins encoded by the viral genome, the matrix protein M1, is abundantly ...
Structural elements in the Gag polyprotein of feline immunodeficiency virus involved in Gag self-association and assembly
(Society for General Microbiology, 2014-09)
The Gag polyprotein of feline immunodeficiency virus (FIV) assembles at the plasma membrane of the infected cells. We aimed to identify the FIV Gag domains that interact and promote Gag multimerization. To do this we ...
Penaeid Shrimp Immune System
(2012-11-22)
Research on an innate immune system of penaeid shrimp is greatly motivated by economical requirements, because their culture is limited by the development of infectious diseases. As invertebrates, shrimp’s natural immunity ...
Redox regulation of the proteasome via S-glutathionylation
(ElsevierAmsterdam, 2014-12-14)
The proteasome is a multimeric and multicatalytic intracellular protease responsible for the degradation of proteins involved in cell cycle control, various signaling processes, antigen presentation, and control of protein ...
Biofabrication of functional protein nanoparticles through simple His-tag engineering
(American Chemical Society Inc, 2021-08-30)
We have developed a simple, robust and fully transversal approach for the a-la-carte fabrication of functional multimeric nanoparticles with potential biomedical applications, validated here by a set of diverse and unrelated ...
Pharmacological evaluation of new meta- and para-hydroxyl substituted C-4-aryl-1,4-dihydropyridines in cardiomyocytes
(2010)
Voltage-dependent calcium channels are widely expressed throughout the different tissues,
including those from the cardiovascular system. They constitute the main route for calcium entry.
Voltage gated calcium channels are ...
Helminths turning on the NLRP3 inflammasome: Pros and cons
(Elsevier, 2020-02)
Helminth infections can activate multimeric protein complexes called inflammasomes. In this forum we summarize the main effects of the NLRP3 inflammasome activation, including control of excessive Th2 response and ...
All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae
(American Society for Cell Biology, 2008-07)
The transfer of lipid-linked oligosaccharide to asparagine residues of polypeptide chains is catalyzed by oligosaccharyltransferase (OTase). In most eukaryotes, OTase is a hetero-oligomeric complex composed of eight different ...