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20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2Ld epitope from a recombinant protein
(2007-04-06)
The majority of MHC class I epitopes is generated through the ubiquitin-proteasome system. In the present study, we have analyzed the proteasome-dependent generation of the IE pp89 MCMV-derived H-2Ld epitope by both in ...
KCTD5 and ubiquitin proteasome signaling are required for Helicobacter pylori adherence
(Frontiers Media SA, 2017)
In order to establish infection, bacterial pathogens modulate host cellular processes by using virulence factors, which are delivered from the bacteria to the host cell leading to cellular reprogramming. In this context, ...
20S Proteasome: Structural study using SAXS.
(Comitê dos Usuários do LNLSCNPEM/LNLSCampinas, 2013-02-26)
The process of intracellular proteolysis (protein degradation) is a regulatory mechanism of cellular homeostasis with the same level of importance as gene expression.The proteasome is a proteolytic complex responsible for ...
Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress
(Elsevier Sci Ireland LtdClareIrlanda, 2002)
Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells
(Mdpi, 2019-06-01)
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test whether conditions ...
The activity of the 20S proteasome is maintained in detached wheat leaves during senescence in darkness
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2002-02)
In the present paper, we studied the participation of the 20S proteasome, the proteolytic component of the ubiquitin-proteasome pathway, in the remobilization of bulk proteins in senescing wheat leaves. The detached leaves ...
The ubiquitin-proteasome system in Strongyloididae. Biochemical evidence for developmentally regulated proteolysis in Strongyloides venezuelensis
(SPRINGER, 2009)
Nematode parasites from the genus Strongyloides spp. are important pathogens of the intestinal mucosa of animals and humans. Their complex life cycles involve alternating developmental adaptations between larvae stages and ...
PROTEASOME ACTIVITY AND ITS RELATIONSHIP WITH PROTEIN PHOSPHORYLATION DURING CAPACITATION AND ACROSOME REACTION IN HUMAN SPERMATOZOA
(S/EDITORIAL, 2007)
We have shown that the proteasome is present in mammalian sperm and plays a role during fertilisation. In this work we studied the relationship between protein phosphorylation and proteasomal activity in human sperm. ...
The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome
The proteasome is the major non-lysosomal proteolytic machine in cells that, through degradation of ubiquitylated substrates, regulates virtually all cellular functions. Numerous accessory proteins influence the activity ...
Cellular responses to proteasome inhibition : Molecular mechanisms and beyond
(2019-07-02)
Proteasome inhibitors have been actively tested as potential anticancer drugs and in the treatment of inflammatory and autoimmune diseases. Unfortunately, cells adapt to survive in the presence of proteasome inhibitors ...