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PI3K/Akt cooperates with oncogenic Notch by inducing nitric oxide-dependent inflammation
(Elsevier B.V., 2018-03)
The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of aggressive cancers. Elucidating how the PI3K/Akt pathway facilitates tumorigenesis by other oncogenes may offer opportunities to ...
Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression
(Impact Journals, 2015-06-08)
Improved efficacy of neoadjuvant endocrine-targeting therapies in luminal breast carcinomas could be achieved with optimal use of pathway targeting agents. In a mouse model of ductal breast carcinoma we identify a tumor ...
Potential use of PI3K pathway effectors and associated microRNAs as biomarkers of breast cancer prognosis
(Fundación Revista Medicina, 2021)
PI3K/AKT/mTOR pathway is frequently altered in breast tumors and has consequently become a promising therapeutic target; therefore, novel biomarkers are in need. In luminal breast cancer cell lines, we have previously found ...
Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
(Springer, 2010-02)
Glypican-3 (GPC3) is a proteoglycan involved in proliferation and cell survival. Several reports demonstrated that GPC3 is downregulated in some tumors, such as breast cancer. Previously, we determined that GPC3 reexpression ...
Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells
(Pergamon-Elsevier Science Ltd, 2019-05-10)
Several epidemiologic studies have revealed strong inverse associations between metformin use and risk of colorectal cancer development. Nevertheless, the underlying mechanisms are still uncertain. The Wnt/β-catenin pathway, ...
Análisis del efecto del gen DJ-1 frente a C2-Ceramida, 6-Hidroxidopamina y rotenona y su relación con la vía PI3K/AKT en un modelo de neuronas mesencefálicas
(2010)
La enfermedad de Parkinson (EP) es un desorden neurodegenerativo caracterizado por pérdida progresiva de neuronas dopaminérgicas de la sustancia nigra y acumulación de cuerpos de Lewy. Recientemente, varios genes han sido ...
A melhora da consolidação da memória induzida por espermidina envolve a ativação da via PI3K/AKT
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2020-10-28)
Memory consolidation is a process that depends on specific brain structures, such as the hippocampus, synthesis of new proteins, activation of protein kinases and neurotrophins, such as the brain-derived neurotrophic factor ...
Meformin and LY294002 treatment regulate angiogenesis process through PI3K-MAPK/AKT/mTOR signaling pathways in mammary tumors.
(Amer Assoc Cancer Research, 2018-01-01)
Linoleic acid induces opening of connexin26 hemichannels through a pi3k/akt/ca2+-dependent pathway
(ELSEVIER SCIENCE BV, 2013)