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Inhibition of in vivo leishmanicidal mechanisms by tempol: Nitric oxide down-regulation and oxidant scavenging
(ELSEVIER SCIENCE INC, 2008)
Tempol (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy) has long been known to protect experimental animals from the injury associated with oxidative and inflammatory conditions. In the latter case, a parallel decrease in ...
Anti-inflammatory Effects of Aerobic Exercise in Mice Exposed to Air Pollution
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2012)
VIEIRA, R. D. P., A. C. TOLEDO, L. B. SILVA, F. M. ALMEIDA, N. R. DAMACENO-RODRIGUES, E. G. CALDINI, A. B. G. SANTOS, D. H. RIVERO, D. C. HIZUME, F. D. T. Q. S. LOPES, C. R. OLIVO, H. C. CASTRO-FARIA-NETO, M. A. MARTINS, ...
Retinal cell death induced by TRPV1 activation involves NMDA signaling and upregulation of nitric oxide synthases
(Kluwer Academic/Plenum PublishersNew York, 2013-01-17)
The activation of the transient receptor potential vanilloid type 1 channel (TRPV1) has been correlated with oxidative and nitrosative stress and cell death in the nervous system. Our previous results indicate that TRPV1 ...
Activation of Survival and Apoptotic Signaling Pathways in Lymphocytes Exposed to Palmitic Acid
(WILEY-BLACKWELLMALDEN, 2012)
The toxicity of palmitic acid (PA) towards a human T-lymphocyte cell line (Jurkat) has been previously investigated but the mechanism(s) of PA action were unknown. In the current study, Jurkat cells were treated with ...
Bioactivity of nitrolinoleate: effects on adhesion molecules and CD40-CD40L system
(ELSEVIER SCIENCE INC, 2010)
The vascular effects of nitrolinoleate (LNO(2)), an endogenous product of linoleic acid (LA) nitration by nitric oxide-derived species and a potential nitrosating agent, were investigated on rat endothelial-leukocyte ...
Stress-induced neuroinflammation: mechanisms and new pharmacological targets
(Associação Brasileira de Divulgação Científica, 2008)
Stress is triggered by numerous unexpected environmental, social or pathological stimuli occurring during the life of animals, including humans, which determine changes in all of their systems. Although acute stress is ...
Cytoprotective mechanisms in rats lung parenchyma with zinc deprivation
(Springer, 2014-02-19)
Suboptimal intake of Zinc (Zn) is one of the most common worldwide nutritional problems. The aim of this study is to provide new evidence on the relation between moderate Zn restriction, and cytoprotective functions ...
Thiol oxidation by nitrosative stress: Cellular localization in human spermatozoa
(Informa Healthcare, 2016-09)
Peroxynitrite is a highly reactive nitrogen species and when it is generated at high levels it causes nitrosative stress, an important cause of impaired sperm function. High levels of peroxynitrite have been shown to ...