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Cancer stem cell genomics: the quest for early markers of malignant progression
(Expert Reviews, 2009-09-01)
Biologically distinct populations of neoplastic stem cells have been identified in a variety of human cancers, in which they are associated with the initial steps of tumorigenesis. the intrinsic properties of self-renewal, ...
Retinoic Acid-Treated Pluripotent Stem Cells Undergoing Neurogenesis Present Increased Aneuploidy and Micronuclei Formation
(PUBLIC LIBRARY SCIENCE, 2011)
The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. ...
Inhibition of Cell Division and DNA Replication Impair Mouse-Naïve Pluripotency Exit
(Academic Press Ltd - Elsevier Science Ltd, 2017-09)
The cell cycle has gained attention as a key determinant for cell fate decisions, but the contribution of DNA replication and mitosis in stem cell differentiation has not been extensively studied. To understand if these ...
MicroRNA characterization in equine induced pluripotent stem cells
(Public Library of Science, 2018-12)
Cell reprogramming has been well described in mouse and human cells. The expression of specific microRNAs has demonstrated to be essential for pluripotent maintenance and cell differentiation, but not much information is ...
Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
(BioMed Central, 2017-10-18)
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally ...
Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease
(BMC, 2014)
Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These ...
Prion potency in stem cells biology
(LANDES BIOSCIENCEAUSTIN, 2012)
Prion protein (PrP) can be considered a pivotal molecule because it interacts with several partners to perform a diverse range of critical biological functions that might differ in embryonic and adult cells. In recent ...
Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells? Transcription Factors
(Public Library of Science, 2015-12)
Pluripotent stem cells possess complex systems that protect them from oxidative stress and ensure genomic stability, vital for their role in development. Even though it has been reported that antioxidant activity diminishes ...