Buscar
Mostrando ítems 31-40 de 221
Strychnine inhibits the binding of glycine to Rat brain-cortex membrane
(1970)
THE excitatory action of strychnine on the central nervous system results from its ability to antagonize the effect of synaptic inhibition1. Recently, evidence has accumulated for glycine as an inhibitory transmitter, ...
From glutamatergic dysfunction to cognitive impairment: Boundaries in the therapeutic of the schizophrenia
(Bentham Science, 2012)
Cognitive deficits are trait markers in schizophrenia and the improvement of these dysfunctions has been considered as a new frontier of treatment in this disease. A current model for the patophysiology of schizophrenia ...
Androgen receptor gene CAG and GGN repeat polymorphisms in Chilean men with primary severe spermatogenic failure
(2010)
There is ample documentation supporting the fact that androgens are required for normal spermatogenesis. A minority of infertile men have abnormal testosterone blood levels or mild androgen receptor mutations. We investigated ...
Mutational Replacements at the “Glycine Hinge” of the Escherichia coli Chemoreceptor Tsr Support a Signaling Role for the C-Helix Residue
(American Chemical Society, 2017-06)
Bacterial chemoreceptors are dimeric membrane proteins that transmit signals from a periplasmic ligand-binding domain to the interior of the cells. The highly conserved cytoplasmic domain consists of a long hairpin that ...
Intact working memory in the absence of forebrain neuronal glycine transporter 1
(Elsevier Science, 2012-04)
Glycine transporter 1 (GlyT1) is a potential pharmacological target to ameliorate memory deficits attributable to N-methyl-d-aspartate receptor (NMDAR) hypofunction. Disruption of glycine-reuptake near excitatory synapses ...
The Effect of Endogenous Modulator Endobain E on NMDA Receptor Is Interfered by Zn 2+ but Is Independent of Modulation by Spermidine
(Springer/Plenum Publishers, 2004-04)
A brain endogenous factor, termed endobain E, allosterically decreases [ 3H]dizocilpine binding to NMDA receptor. Such effect depends on receptor activation by the coagonists glutamate and glycine and is interfered by ...