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Mostrando ítems 31-40 de 62
Avaliação da expressão de hepcidina e ferroportina na linhagem celular DU145 após tratamento com compostos heparínicos
(Universidade Federal de São Paulo, 2022-08)
Introdução: O câncer de próstata é a neoplasia mais frequente e a principal causa de morte nos indivíduos do sexo masculino acometidos, em todo Brasil. Devido à progressão da doença para estágios avançados e que apresentam ...
Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies
(Sociedad de Biología de Chile, 2006)
Analysis of HFE and non-HFE gene mutations in Brazilian patients with hemochromatosis
(Faculdade de Medicina / USP, 2009)
BACKGROUND: Approximately one-half of Brazilian patients with hereditary hemochromatosis (HH) are neither homozygous for the C282Y mutation nor compound heterozygous for the H63D and C282Y mutations that are associated ...
Impacto da inflamação na regulação do ferro e deficiência funcional de ferro
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2010-06-01)
Functional iron deficiency can be defined as an imbalance between the iron needs of the erythroid marrow and iron supply. Iron deficiency occurs in the absence of iron deposits, as in the case of iron deficiency anemia ...
Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein
(Elsevier, 2017)
Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are
pathophysiological features in a number of neurodegenerative processes. The question arises as to whether ...
Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
(2013)
Inflammation and iron accumulation are present in a variety of
neurodegenerative diseases that include Alzheimer’s disease
and Parkinson’s disease. The study of the putative association
between inflammation and iron ...
Inflaming the brain with iron
(MDPI, 2021)
Iron accumulation and neuroinflammation are pathological conditions found in several neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Iron and inflammation are intertwined in a ...
Hereditary hemochromatosis: An opportunity for gene therapy
(Sociedad de Biología de Chile, 2006)
Hereditary hemochromatosis: Mutations in genes involved in iron homeostasis in Brazilian patients
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Background: p.C282Y mutation and rare variants in the HFE gene have been associated with hereditary hemochromatosis (HH). HH is also caused by mutations in other genes, such as the hemojuvelin (HJV), hepcidin (HAMP), ...