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Mostrando ítems 31-40 de 108
Estrategias para el desarrollo de nuevas herramientas para la edición genética en Paracoccidioides spp.: un acercamiento a la tecnología CRISPR/Cas9
(Biología Celular y Molecular CIB U. de A. U. del RosarioMedellín - Colombia, 2022)
Generación de líneas celulares estables knock-out para PRPK mediante CRISPR/CAS9
(Universidad de Chile, 2023)
This work describes the creation and characterization of human neuroblastoma SH-SY5Y lines knock-out for PRPK (P53 Related Protein Kinase), a poorly characterized kinase with a role related to the regulation of axon ...
Análise estrutural e funcional de proteínas de grânulos densos de Toxoplasma gondii através da edição gênica por CRISPR/CAS9Structural and functional analysis of Toxoplasma gondii dense granule proteins through the genetic editing using CRISPR / CAS9
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Imunologia e Parasitologia Aplicadas, 2018)
Rapid, selection-free, high-efficiency genome editing in protozoan parasites using CRISPR-cas9 ribonucleoproteins
(American Society for Microbiology, 2017-11-07)
Trypanosomatids (order Kinetoplastida), including the human pathogens Trypanosoma cruzi (agent of Chagas disease), Trypanosoma brucei, (African sleeping sickness), and Leishmania (leishmaniasis), affect millions of people ...
Perfil proteômico de podócitos editados geneticamente pela tecnologia CRISPR/Cas9 expressando características fenotípicas da doença de Fabry
(Universidade Federal de São Paulo, 2022-09-01)
Introdução: Lesão dos podócitos e subsequente nefropatia crônica progressiva são características proeminentes da Doença de Fabry (DF), desordem de depósito lisossômico com padrão de herança ligada ao X provocada por ...
New players in neuronal Iron homeostasis: insights from CRISPRi studies
(MDPI, 2022)
Selective regional iron accumulation is a hallmark of several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The underlying mechanisms of neuronal iron dyshomeostasis have been studied, ...
Relación virus-hospedero en ambientes termales: especificidad y ecogenómica de sistemas CRISPR-Cas
(2023)
La relación virus-hospedero se ha estudiado en varios ensayos dentro de los laboratorios, mientras que se han realizado comparativamente pocas descripciones en ambientes naturales. Entre estos, los ambientes de alta ...
Global phylogenomic novelty of the Cas1 gene from hot spring microbial communities
(2022)
The Cas1 protein is essential for the functioning of CRISPR-Cas adaptive systems. However, despite the high prevalence of CRISPR-Cas systems in thermophilic microorganisms, few studies have investigated the occurrence and ...
Balance between retroviral latency and transcription : based on HIV model
(MDPI, 2021-01)
The representative of the Lentivirus genus is the human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). To date, there is no cure for AIDS because of the existence ...
Estudo molecular da resistência a bacteriófagos líticos em Salmonella enterica subsp. enterica serovar Enteritidis
(Universidade Estadual Paulista (Unesp), 2015-08-03)
Salmonella Enteritidis is a pathogen that belongs to the Enterobacteriaceae family and is often related to infections transmitted by food in humans, especially in children, elderly and immunosuppressed patients. The ...