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β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation
(Academic Press Inc., 2019)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The ...
Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
(Wiley, 2020)
Potentially malignant lesions, commonly referred to as dysplasia, are associated with malignant transformation by mechanisms that remain unclear. We recently reported that increased Wnt secretion promotes the nuclear ...
Expression profile of components of the beta-catenin destruction complex in oral dysplasia and oral cancer
(Medicina Oral, 2021)
Background: Oral cancer represents the sixth most common cancer in the world and is associated with 40-50%
survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by
potentially ...
Increased nuclear beta-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia
(Medicina Oral, 2015)
Background: Deregulation of beta-catenin is associated with malignant transformation; however, its relationship with potentially malignant and malignant oral processes is not fully understood. The aim of this study was to ...
Increased nuclear β-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia
(Medicina Oral, Patologia Oral y Cirugia Bucal, 2015)
Background: Deregulation of β-catenin is associated with malignant transformation; however, its relationship with potentially malignant and malignant oral processes is not fully understood. The aim of this study was to ...
Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
(Company of Biologists, 2011-06)
The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal ...
WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis
(John Wiley and Sons, 2009)
Oncogenic Wnt/b-catenin signaling
occurs in numerous types of cancers, but little is known
about the role of the Wnt protein family member, WNT-
5A, in lip carcinogenesis. The aim of this study was to
investigate WNT-5A, ...
TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells
(John Wiley and Sons Ltd., 2018)
Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing ...
The effects of genistein and daidzein on cell proliferation kinetics in HT29 colon cancer cells: the expression of CTNNBIP1 (beta-catenin), APC (adenomatous polyposis coli) and BIRC5 (survivin)
(Springer, 2014-04-01)
Soybean isoflavonoids have received significant attention due to their potential anticarcinogenic and antiproliferative effects and possible role in many signal transduction pathways. However, their mechanisms of action ...
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background: Oncogenic Wnt/beta-catenin signaling occurs in numerous types of cancers, but little is known about the role of the Wnt protein family member, WNT-5A, in lip carcinogenesis. The aim of this study was to investigate ...