info:eu-repo/semantics/article
Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus
Fecha
2011-06Registro en:
Acosta , Helena; Lopez, Silvia Liliana; Revinski, Diego Raul; Carrasco, Andres Eduardo; Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus; Company of Biologists; Development; 138; 12; 6-2011; 2567-2579
0950-1991
CONICET Digital
CONICET
Autor
Acosta , Helena
Lopez, Silvia Liliana
Revinski, Diego Raul
Carrasco, Andres Eduardo
Resumen
The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain. © 2011. Published by The Company of Biologists Ltd.