Buscar
Mostrando ítems 31-40 de 344
Mecanismos de señalización por β-catenina y su papel en la carcinogénesisβ-catenin signaling mechanisms and its role in carcinogenesis
(Universidad CES, Facultad de MedicinaGrupo de GastrohepatologíaMedellín, Colombia, 2022)
Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
(Cell Press, 2020-06)
Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program initiated during oocyte maturation with translation of stored maternal mRNAs. Here, we show that tankyrase, a poly(ADP-ribosyl) ...
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease
(Blackwell Publishing Ltd, 2016)
© 2016 International Society for Neurochemistry Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's ...
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription
(BioMed Central Ltd., 2014)
© 2014 Fernández et al.; licensee BioMed Central Ltd.Early in cancer development, tumour cells express vascular endothelial growth factor (VEGF), a secreted molecule that is important in all stages of angiogenesis, an ...
Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells
(Elsevier B.V., 2019)
© 2018The in vitro process of chondrogenic differentiation of mesenchymal stem cells (MSCs) induces a pre-apoptotic hypertrophic phenotype, guided by the active status of the WNT/β‑catenin pathway. To achieve a stable ...
WNT Signaling Is a Key Player in Alzheimer’s Disease
(Springer Science and Business Media Deutschland GmbH, 2021)
The cellular processes regulated by WNT signaling have been mainly studied during embryonic development and cancer. In the last two decades, the role of WNT in the adult central nervous system has been the focus of interest ...
Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells
(Pergamon-Elsevier Science Ltd, 2019-05-10)
Several epidemiologic studies have revealed strong inverse associations between metformin use and risk of colorectal cancer development. Nevertheless, the underlying mechanisms are still uncertain. The Wnt/β-catenin pathway, ...