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Telomerase activity in the vaginal margins of radical hysterectomy in patients with carcinoma of the cervix: Correlation with histology and human papillomavirus
(2006-05-01)
This study was undertaken to evaluate the telomerase activity both in the tumor and in the vaginal margins of radical hysterectomy in patients with squamous cell carcinoma (SCC) of the cervix. Thirty-three patients with ...
Telomerase activity in the vaginal margins of radical hysterectomy in patients with carcinoma of the cervix: Correlation with histology and human papillomavirus
(2006-05-01)
This study was undertaken to evaluate the telomerase activity both in the tumor and in the vaginal margins of radical hysterectomy in patients with squamous cell carcinoma (SCC) of the cervix. Thirty-three patients with ...
AZT on telomerase activity and cell proliferation in HS 839.T melanoma cells
(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2012-12-01)
PURPOSE: To evaluate telomerase activity and proliferation of HS839.T melanoma cells, subjected to the action of AZT. METHODS: Cells were grown in triplicate, AZT at different concentrations: 50, 100 and 200μM, was added ...
Aplicação das enzimas lipase, protease e telomerase em “cosméticos verdes”: uma revisão de literatura
(Universidade Federal do Rio Grande do NorteBrasilUFRNfarmácia, 2021-04-09)
The cosmetics market tends to grow more and more, especially when it comes to green cosmetics which are natural, organic, vegan and cruelty free products. This is because the population has become more aware of the harmful ...
Effect of chemotherapeutic drugs on telomere length and telomerase activity
(Smart Science & Technology, 2016-12)
Telomeres are specialized nucleoproteic complexes localized at the ends of eukaryotic chromosomes, that maintain their stability and integrity. They protect chromosome ends from fusion and from being recognized as sites ...
TRAP-silver staining, a highly sensitive assay for measuring telomerase activity in tumor tissue and cell lines
(Associação Brasileira de Divulgação Científica, 2002-01-01)
Measurement of telomerase activity in clinically obtained tumor samples may provide important information for use as both a diagnostic marker and a prognostic indicator for patient outcome. In order to evaluate telomerase ...
Telomerase inhibition by a new synthetic derivative of the aporphine alkaloid boldine
(MDPI, 2018-04)
Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. ...
Increased in vitro glial fibrillary acidic protein expression, telomerase activity, and telomere length after productive human immunodeficiency virus-1 infection in murine astrocytes
(Wiley, 2014-02)
Although HIV-associated neurocognitive disorders (HAND) result from injury and loss of neurons, productive infection routinely takes place in cells of macrophage lineage. In such a complex context, astrocytosis induced by ...
Homology model and docking-based virtual screening for ligands of human dyskerin as new inhibitors of telomerase for cancer treatment
(Molecular Diversity Preservation International, 2018-10)
Immortality is one of the main features of cancer cells. Tumor cells have an unlimited replicative potential, principally due to the holoenzyme telomerase. Telomerase is composed mainly by dyskerin (DKC1), a catalytic ...
Avaliação da atividade da telomerase em células-tronco de pacientes com displasia cortical de Taylor
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
The Cortical dysplasia is one of the most frequent forms of malformations of cortical development, with a condition that causes a large portion of refractory partial epilepsy to drug treatment. This condition is characterized ...