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Tau oligomers and fibrils induce activation of microglial cells
(IOS Press, 2013)
Neuroinflammation is a process related to the onset of several neurodegenerative disorders, including Alzheimer's disease (AD). Increasing sets of evidence support the major role of deregulation of the interaction patterns ...
Targeting of mRNAs within the glial cell cytoplasm: how to hide the message along the journey
(Wiley-liss, Div John Wiley & Sons Inc, 2000-11)
The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain ...
Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni
(1989-11-01)
A morphological, karyometric, and quantitative study of cerebral neuroglia and endothelial cells of blood capillaries was done in cirrhotic and in hepatosplenic schistosomotic human autopsied cases. Cluster analysis applied ...
Editorial: Glial cells, maladaptive plasticity, and neurodegeneration: Mechanisms, targeted therapies, and future directions
(Frontiers Media S.A., 2021-04-30)
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience. Morphological organization of the CNS represents the basis for its functional properties underlying higher brain ...
Emotional stress induces structural plasticity in Bergmann glial cells via an AC5–CPEB3–GluA1 pathway
(Society for Neuroscience, 2020-04)
Stress alters brain function by modifying the structure and function of neurons and astrocytes. The fine processes of astrocytes are critical for the clearance of neurotransmitters during synaptic transmission. Thus, ...
Astrocyte responses in human optic nerve head with primary open-angle glaucoma
(1997)
Purpose: To identify and characterize astrocyte responses and reactivation in human optic nerve heads from patients with primary open-angle glaucoma. Methods: Fifteen optic nerve heads with primary open-angle glaucoma and ...
Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases
(Current Pharmaceutical Design, 2018-07-30)
Glial cells (also known as glia or neuroglia) are structures which are found in large numbers throughout the nervous system, fulfilling multiple functions, such as regulating the synapses, providing structure, support and ...
Editorial: Modulating glial cells phenotype. New findings and therapies
(Frontiers Media, 2020-09-23)
Aging and neurodegenerative diseases are closely related, and the common point between both scenarios is neuroinflammation. Neuroinflammation is mainly mediated by glial cells, astrocytes, and microglia; while endothelial ...
Müller glial cells induce stem cell properties in retinal progenitors in vitro and promote their further differentiation into photoreceptors
(Wiley, 2012-10-04)
Using stem cells to replace lost neurons is a promising strategy for treating retinal neurodegenerative diseases. Among their multiple functions, Müller glial cells are retina stem cells, with a robust regenerative potential ...
Ceramide-1-phosphate promotes the migration of retina Müller glial cells
(Elsevier Science Ltd, 2020-11-13)
Müller glial cells, the major glial cell type in the retina, are activated by most retina injuries, leading to an increased proliferation and migration that contributes to visual dysfunction. The molecular cues involved ...