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RUNX family: Oncogenes or tumor suppressors
(Facultad de Medicina y Ciencia, 2019)
Runt-related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated ...
Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
(COMPANY OF BIOLOGISTS LTD, 2004-04-15)
Stardust (Sdt) and Discs-Large (Dig) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila. Loss of ...
Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg's Discovery
(Karger, 2011-01-01)
Cancer cells are the product of genetic disorders that alter crucial intracellular signaling pathways associated with the regulation of cell survival, proliferation, differentiation and death mechanisms. the role of oncogene ...
The long arm of BRAF V600E gets to mTORC1
(Wiley, 2009-03)
Despite the disappointing results of early clinical studies, targeting the BRAF ⁄ MEK⁄ extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK) pathway is still a subject of investigation due ...
Frequent p53 mutations and occasional loss of chromosome 4 in invasive bladder carcinoma induced by N-butyl-N-(4-hydroxybutil)nitrosamine in B6D2F1 mice
(1998-03-16)
B6D2F1 mice (45/group) were treated with N-butyl-N-(4- hydroxybutyl)nitrosamine (BBN) or uracil as follows: Group 1 received 0.05% BBN in drinking water for the entire experiment, Group 2 received 5 mg of BBN by gastric ...
Frequent p53 mutations and occasional loss of chromosome 4 in invasive bladder carcinoma induced by N-butyl-N-(4-hydroxybutil)nitrosamine in B6D2F1 mice
(1998-03-16)
B6D2F1 mice (45/group) were treated with N-butyl-N-(4- hydroxybutyl)nitrosamine (BBN) or uracil as follows: Group 1 received 0.05% BBN in drinking water for the entire experiment, Group 2 received 5 mg of BBN by gastric ...
The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53
(Elsevier Science BvAmsterdamHolanda, 2005)