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Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca2+- permeable TRPC6 channels
(Wiley, 2012-07)
The standardized extract of the St. John's wort plant (Hypericum perforatum) is commonly used to treat mild to moderate depression. Its active constituent is hyperforin, a phloroglucinol derivative that reduces the reuptake ...
Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels
(Molecular Diversity Preservation International, 2020-01)
TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been ...
TRPC3 regulates islet beta-cell insulin secretion
(Wiley, 2023)
TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice
(Wiley, 2017)
Abstract: Canonical transient receptor potential (TRPC) channels constitute a family of cation channels that exhibit a regional and cell-specific expression pattern throughout the brain. It has been reported previously ...
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory
(Elsevier Science, 2015-03)
Memory formation requires de novo protein synthesis, and memory disorders may result from misregulated synthesis of critical proteins that remain largely unidentified. Plasma membrane ion channels and receptors are likely ...
Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel
(National Academy of Sciences, 2015-04)
In previous in vitro studies, we showed that Transient Receptor Potential Canonical 3 (TRPC3), a calcium-permeable, nonselective cation channel endowed with high constitutive function, is an obligatory component of ...
RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways
(Nature, 2020-05)
The seven-member transient receptor potential canonical genes (TRPC1-7) encode cation channels linked to several human diseases. There is little understanding of the participation of each TRPC in each pathology, considering ...
The multimeric structure of polycystin-2 (TRPP2): Structural - Functional correlates of homo- and hetero-multimers with TRPC1
(Oxford University Press, 2009-04)
Polycystin-2 (PC2, TRPP2), the gene product of PKD2, whose mutations cause autosomal dominant polycystic kidney disease (ADPKD), belongs to the superfamily of TRP channels. PC2 is a non-selective cation channel, with ...