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Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis
(Amer Physiological Soc, 2013-08-01)
In catabolic conditions such as aging and diabetes, IGF signaling is impaired and fibrosis develops in skeletal muscles. To examine whether impaired IGF signaling initiates muscle fibrosis, we generated IGF-IR+/- heterozygous ...
Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-β signaling
(2007)
The endothelial nitric oxide synthase (eNOS) is a critical regulator of cardiovascular homeostasis, whose dysregulation leads to different vascular pathologies. Endoglin is a component of the transforming growth factor ...
Hepatic fibrogenesis and transforming growth factor/Smad signaling activation in rats chronically exposed to low doses of lead
(Wiley, 2013-11)
Lead is an important heavy metal pollutant in the environment. The nervous system, kidney and liver are the most susceptible organs to lead deposition, showing that this pollutant has no single target system. To examine ...
Neuronal loss and abnormal BMP/Smad signaling in the myenteric plexus of diabetic rats
(Elsevier Science, 2011-10)
Bone morphogenetic proteins (BMPs) are critical molecules during gut morphogenesis. However, little is known about their participation in the homeostasis of adult gut and their possible role in diseases. Gastrointestinal ...
Interferon-a2b and transforming growth factor-b1 treatments on HCC cell lines: are Wnt/b-catenin pathway and Smads signaling connected in hepatocellular carcinoma?
(Elsevier Inc, 2011-12)
Wnt/b-catenin pathway is often dysregulated in hepatocellular carcinoma (HCC). Activated b-catenin accumulates in the cytosol and nucleus and forms a nuclear complex with TCF/LEF factors like TCF4. Interferon-a (IFN-a) has ...
The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding
(BioMed Central, 2013-12)
Background: The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors. This prompted us to ...
Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
(2012)
Leishmania braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. In the mouse, Fli1 was identified as a gene influencing enhanced wound healing and resistance to CL caused by Leishmania major. Polymorphism at ...
Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts
(Wiley-blackwellMaldenEUA, 2012)