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Liver protective effects of extra virgin olive oil: interaction between Its chemical composition and the cell-signaling pathways involved in protection
(Bentham Science Publ LTD, 2018)
Background and Objective: The liver is an organ susceptible to a multitude of injuries that causes liver damage, like steatosis, non-alcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and ischemia-reperfusion ...
Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells
(Elsevier Science, 2018-09)
Multidrug resistance-associated protein 2 (MRP2) plays a key role in hepatic and intestinal disposition of endo- and xenobiotics. Several therapeutic agents modulate MRP2 activity resulting in pharmacological interactions. ...
Folic acid supplementation during early hepatocarcinogenesis: cellular and molecular effects
(Wiley-Blackwell, 2011-11-01)
Folic acid (FA) supplementation during carcinogenesis is controversial. Considering the impact of liver cancer as a public health problem and mandatory FA fortification in several countries, the role of FA supplementation ...
β-ionone inhibits nonalcoholic fatty liver disease and its association with hepatocarcinogenesis in male Wistar rats
(2019-08-01)
Among the primary neoplasias that affect the liver, hepatocellular carcinoma (HCC) is the most frequent and the third leading cause of death related to cancer. Several risk factors predispose individuals to HCC such as ...
The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis
(2016-02-01)
Scope: Emerging evidence indicates that the use of bioactive food components is a promising strategy to prevent the development of liver cancer. The goal of this study was to examine the chemopreventive effect of ...
Avaliação da atividade anti-Mycobacterium tuberculosis in vitro e in vivo em modelo alternativo Galleria mellonella de análogos monocetônicos de curcumina
(Universidade Estadual Paulista (Unesp), 2021-03-16)
A tuberculose (TB) é a doença infecciosa mais mortal do mundo, de acordo com a Organização Mundial da Saúde (OMS) foram relatados 10 milhões de novos casos mundiais de TB apenas em 2019, dentre eles houve 1,4 milhão de ...
Análise dos efeitos da resistência à insulina central sobre o metabolismo de glicose hepático em modelo animal da doença de Alzheimer
(Universidade Federal de São Paulo, 2022-12-15)
O diabetes mellitus (DM) é um distúrbio metabólico amplamente estudado e que aparenta ter uma relação com outras doenças que envolvem o metabolismo energético. Uma destas doenças é a doença de Alzheimer (DA), já que ...