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Phospholipase D and phosphatidate phosphohydrolase activities in rat cerebellum during aging
(Springer Heidelberg, 2004-06-01)
Aging is a process that affects different organs, of which the brain is particularly susceptible. PA and DAC are central intermediates in the phosphoglyceride as well as in the neutral lipid biosynthetic pathway, and they ...
Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons
(WILEY-BLACKWELL, 2011-09)
Nitric oxide (NO) has been proposed to down-regulate NMDA receptors (NMDA-Rs) in a homeostatic manner. However, NMDA-R-dependent NO synthesis also can cause excitotoxic cell death. Using bicuculline-stimulated hippocampal ...
Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats
(2017)
Background: Increased locomotor activity in response to the same stimulus is an index of behavioral sensitization observed in preclinical models of drug addiction and compulsive behaviors. Repeated administration of ...
Efeito da quercetina na atividade de ectoenzimas e da acetilcolinesterase em sinaptossomas do córtex cerebral de ratos expostos ao cádmio
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2012-02-27)
Cadmium (Cd) is one of the most toxic heavy metals by their ability to affect the vital
organs like liver, kidney, brain and other. This metal can trigger a framework of
oxidative stress by increase of reactive oxygen ...
Estudo do sistema purinérgico e colinérgico no encéfalo de animais submetidos à hipoperfusão encefálica crônica e ao ambiente enriquecido
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2016-08-19)
Chronic cerebral hypoperfusion (CCH) has frequently been associated with neurodegenerative diseases. A persistent reduction of cerebral blood flow (CBF) changes the neuronal homeostasis causing diffuse ischemic damage and ...
Effect of synthetic steroids on GABAA receptor binding in rat brain
(Elsevier, 2015-02)
Neuroactive steroids (NAS), like allopregnanolone (A) and pregnanolone (P), bind to specifics sites on the GABAA receptor complex and modulate receptor function. They are capable to inhibit or stimulate the binding of GABAA ...
Consequences of postnatal stress: maternal separation in rats induces long-lasting changes on glutamate transporters
(OMICS International, 2013-03)
Background: There is increasing evidence that environmental factors, particularly stressful events experienced early in life, increase the risk of developing a psychiatric illness and/or a behavioural disorder. The aim of ...
Efeito neuroprotetor da creatina e avaliação dos parâmetros cinéticos da captação de glutamato induzidos pelo ácido glutárico no estriado de ratos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2008-10-14)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM) biochemically characterized by the main accumulation of glutaric acid (GA) and 3- hydroxyglutaric acid (3-OH-GA), and pathologically by a characteristic ...