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Regulatory T cells in dogs with multicentric lymphoma: peripheral blood quantification at diagnosis and after initial stage chemotherapy
(Arquivo Brasileiro Medicina Veterinaria Zootecnia, 2016-01-01)
Lymphoma is the most common hematopoietic malignancy in dogs and one of the most frequent among all neoplastic diseases in this species. It can occur in several anatomical locations with distinct histological and ...
Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii
(2020-09-01)
The role of regulatory T cells (Tregs) on protective immunity in fungal infections, is controversial. Sporotrichosis is an emerging and worldwide-distributed subcutaneous mycosis caused by various related thermodimorphic ...
Relationship of regulatory T cells to Plasmodium falciparum malaria symptomatology in a hypoendemic region
(BMC, 2014)
Background: Previous data have suggested that regulatory T cells (Tregs) balance protective immune responses with immune mediated pathology in malaria. This study aimed to determine to test the hypothesis that Treg proportions ...
Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications in human reproduction
(American Association of Immunologists, 2007-02)
Regulatory T cells (Tregs) are thought to affect the severity of various infectious and autoimmune diseases. The incidence of autoimmune disease is higher in fertile women than in men. Thus, we investigated whether Treg ...
Regulatory and effector T-cells are differentially modulated by Dexamethasone
(Elsevier, 2013-12)
It is assumed that the ratio between effector T cells (Teff) and regulatory T cells (Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study was to investigate if Dexamethasone (Dex) ...
Vitamin D modulates the transcription factors of T cell subsets to anti-inflammatory and regulatory profiles in preeclampsia
(2021-01-01)
Vitamin D (VD) is a multifunctional prohormone and low VD status in pregnancy may contribute to the risk of adverse perinatal outcomes, such as preeclampsia (PE). This molecule may modulate the polarization of T cell subsets ...
Regulatory T cells and vaccine effectiveness in older adults. Challenges and prospects
(2021-07-01)
Since the discovery of lymphocytes with immunosuppressive activity, increasing interest has arisen in their possible influence on the immune response induced by vaccines. Regulatory T cells (Tregs) are essential for ...
T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance
(Wiley, 2020)
T regulatory (Treg) cells have a major role in the maintenance of immune tolerance against self and foreign antigens through the control of harmful inflammation. Treg cells exert immunosuppressive function by several ...
Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
(Public Library Science, 2017)
Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been successfully
utilized to treat graft versus host disease and represents a promising strategy for the
treatment of autoimmune diseases and ...