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Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications
(American Physiological Society, 2020-02)
The pedunculopontine nucleus (PPN) is part of the reticular activating system (RAS) in charge of arousal and rapid eye movement sleep. The presence of high-frequency membrane oscillations in the gamma-band range in the PPN ...
The Critical Role of Intrinsic Membrane Oscillations
(Karger, 2019-04)
Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations ...
Role of G-proteins in the effects of leptin on pedunculopontine nucleus neurons
(Wiley, 2013-06)
The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system, regulates waking and rapid eye movement sleep. Here, we demonstrate immunohistochemical labeling of the leptin receptor signaling ...
Pedunculopontine arousal system physiology – implications for insomnia
(Elsevier Science, 2015-04)
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly ...
Mechanism behind gamma band activity in the pedunculopontine nucleus
(Wiley, 2011-07)
The pedunculopontine nucleus (PPN), part of the reticular activating system, modulates waking and paradoxical sleep. During waking and paradoxical sleep, EEG responses are characterized by low-amplitude, high-frequency ...
Recording gamma band oscillations in pedunculopontine nucleus neurons
(JoVE, 2016-09)
Synaptic efferents from the PPN are known to modulate the neuronal activity of several intralaminar thalamic regions (e.g., the centrolateral/ parafascicular; Cl/Pf nucleus). The activation of either the PPN or Cl/Pf nuclei ...
Alteration of mesopontine cholinergic function by the lack of KCNQ4 subunit
(Frontiers Media S.A., 2021-07-26)
The pedunculopontine nucleus (PPN), a structure known as a cholinergic member of the reticular activating system (RAS), is source and target of cholinergic neuromodulation and contributes to the regulation of the ...
Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
(Frontiers, 2014-10)
The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high-frequency EEG activity. Recently,we described the presence of high ...
Muscarinic modulation of high frequency oscillations in pedunculopontine neurons
(Frontiers Research Foundation, 2013-11)
We previously reported that persistent application of the non-specific cholinergic agonist carbachol (CAR) increased the frequency of calcium channel-mediated oscillatory activity in pedunculopontine nucleus (PPN) neurons, ...
Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
(Parkinson's Disease FoundationMacmillan Publishers Limited, 2016)
Abstract: In view of its ability to explain the most frequent motor symptoms of Parkinson’s Disease (PD), degeneration of dopaminergic neurons has been considered one of the disease’s main pathophysiological features. ...