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A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes
(2022)
Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other pancreatic cells raises the questions of the efficiency of the process and of the functionality of the new Insulin-expressing cells. To ...
A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes
(2022)
Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other pancreatic cells raises the questions of the efficiency of the process and of the functionality of the new Insulin-expressing cells. To ...
Necrosis Pancreatic Infectious Virus does not block 701-STAT1 (α/β) tyrosine in Oncorhynchus mykiss (Salmoniformes: Salmonidae).
(Universidad Estatal a Distancia, Costa Rica, 2020)
Properties of voltage-gated Ca2+ currents measured from mouse pancreatic β-cells in situ
(Society of Biology of Chile, 2006)
We used the single-microelectrode voltage-clamp technique to record ionic currents from pancreatic β-cells within intact mouse islets of Langerhans at 37C, the typical preparation for studies of glucose-induced "bursting" ...
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.
(2013-07-08)
Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these
signals to regulation of β-cell mass are not completely understood. Recent findings indicate ...
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells
(1996-12-13)
Interleukin-1 (IL-1) may be a mediator of β-cell damage in insulin-dependent diabetes mellitus (IDDM). The IL-1 mechanism of action on insulin-producing cells probably includes activation of the transcription nuclear factor ...
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells
(1996-12-13)
Interleukin-1 (IL-1) may be a mediator of β-cell damage in insulin-dependent diabetes mellitus (IDDM). The IL-1 mechanism of action on insulin-producing cells probably includes activation of the transcription nuclear factor ...
Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid
(2011-11-15)
Chronic administration of glucocorticoids induces insulin resistance that is compensated by an increase in β-cell function and mass. Since insulin signaling is involved in the control of β-cell function and mass, we ...
Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells
(Public Library Of Science, 2016-02)
Constitutive expression of active Akt (Akttg) drives hyperplasia and hypertrophy of pancreatic β-cells, concomitantly with increased insulin secretion and improved glucose tolerance, and at a later stage the development ...