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The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission
(Elsevier, 2018-08)
The nicotinic acetylcholine receptor (nAChR) has crucial functions at the neuromuscular junction (NMJ). It belongs to the superfamily of pentameric ligand-gated ion channels and has become the stereotype for probing ...
Lithium causes diferential efects on postsynaptic stability in normal and denervated neuromuscular synapses
(Springer Nature, 2021)
Abstract: Lithium chloride has been widely used as a therapeutic mood stabilizer. Although cumulative evidence
suggests that lithium plays modulatory efects on postsynaptic receptors, the underlying mechanism
by which ...
Evaluación de las alteraciones morfológicas y morfométricas de las uniones neuromusculares del diafragma denervado en ratas
(2009-01-01)
The morphological and structural alterations that occur in the neuromuscular junctions of the denervated rat diaphragm were studied. Fifteen adult male albino rats (Rattus norvegicus) aged about 60 days and with a mean ...
Neuromuscular paralysis by the basic phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage
(2017-11-01)
Background and purpose Crotoxin (CTX), a heterodimeric phospholipase A2 (PLA2) neurotoxin from Crotalus durissus terrificus snake venom, promotes irreversible blockade of neuromuscular transmission. Indirect electrophysiological ...