Artigo
Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis
Registro en:
Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 96, p. 46-49, 2015.
0041-0101
10.1016/j.toxicon.2015.01.006
WOS:000350922700005
9353490382598257
Autor
Garrido Cavalcante, Walter Luis [UNESP]
Ponce-Soto, Luis Alberto
Marangoni, Sergio
Gallacci, Marcia [UNESP]
Resumen
A myographic study was performed to compare the neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis in mice phrenic-diaphragm preparation. It was concluded that both venoms present neurotoxic activity as a consequence of their crotoxin content. Furthermore, crotoxin from C.d. cumanensis is more potent than that from C.d. ruruima venom. At the concentration range in which both venoms express neurotoxic activity, only C.d. cumanensis venom also manifest a direct myotoxic effect that probably involves the synergic participation of other components than crotoxin. (C) 2015 Elsevier Ltd. All rights reserved. Sao Paulo State University (UNESP), Bioscience Institute of Botucatu, Botucatu, SP, Brazil University of Campinas (UNICAMP), Biological Institute, Campinas, SP, Brazil Sao Paulo State University (UNESP), Bioscience Institute of Botucatu, Botucatu, SP, Brazil