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Are microtubules tension sensors?.
Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical ...
A Dynamical Model of Kinesin-Microtubule Motility Assays
(Cell Press, 2001-06)
A two-dimensional stochastic model for the dynamics of microtubules in gliding-assay experiments is presented here, which includes the viscous drag acting on the moving fiber and the interaction with the kinesins. For this ...
Model of a depolymerizing microtubule [Microtubule depolymerization as a biological machine]
(The American Society for Cell Biology, ASBC Image & Video Library, 2013)
Model of a depolymerizing microtubule [Microtubule depolymerization as a biological machine]
(The American Society for Cell Biology, ASBC Image & Video Library, 2016)
One-parameter nonrelativistic supersymmetry for microtubules
(Elsevier Science BV, 2003)
Fragment-Based QSAR and Molecular Modeling Studies on a Series of Discodermolide Analogs as Microtubule-Stabilizing Anticancer Agents
(WILEY-V C H VERLAG GMBH, 2009)
Inhibition of microtubule function is an attractive rational approach to anticancer therapy. Although taxanes are the most prominent among the microtubule-stabilizers, their clinical toxicity, poor pharmacokinetic properties, ...
Back in mitosis: waltz of the microtubules
(The American Society for Cell Biology, ASBC Image & Video Library, 2016)
Back in mitosis: waltz of the microtubules
(The American Society for Cell Biology, ASBC Image & Video Library, 2011)
The β-isoform of heat shock protein hsp-90 is structurally related with human microtubule-interacting protein Mip-90
(1999)
Through major research advances in the study of cytoskeletal organization, an integrated view of the complexity of this system has emerged. Recent findings on the microtubule-interacting protein Mip-90, which associates ...
Exchange of microtubule molecular motors during melanosome transport in Xenopus laevis melanophores is triggered by collisions with intracellular obstacles
(Humana Press, 2008-12)
The observation that several cargoes move bidirectionally along microtubules in vivo raised the question regarding how molecular motors with opposed polarity coordinate during transport. In this work, we analyzed the switch ...