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Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative
(Elsevier Science, 2012-01)
There are no specific approved drugs for the treatment of agents of viral hemorrhagic fevers (HF) and antiviral therapies against these viruses are urgently needed. The present study characterizes the potent and selective ...
Participation of eIF4F complex in Junin virus infection: blockage of eIF4E does not impair virus replication
(Wiley, 2013-10)
Translation efficiency of viral mRNAs is a key factor defining both cytopathogenicity and virulence of viruses, which are entirely dependent on the cellular translation machinery to synthesize their proteins. This dependence ...
Desarrollo de una plataforma de presentación y vehiculización de antígenos basada en VLPs derivadas del virus Junín
(Universidad Nacional de Quilmes, 2017-03-31)
Las vacunas más exitosas utilizadas en la actualidad han sido desarrolladas utilizando métodos convencionales que siguen el paradigma establecido por Pasteur hace más de un siglo, de "aislar, inactivar e inyectar” el ...
Role of the ERK1/2 signaling pathway in the replication of junín and tacaribe viruses
(MDPI, 2018-04)
We have previously shown that the infection of cell cultures with the arenaviruses Junín (JUNV), Tacaribe (TCRV), and Pichindé promotes the phosphorylation of mitogen-activated protein kinases (MAPKs) extracellular ...