Buscar
Mostrando ítems 21-30 de 904
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin
(Elsevier B.V., 2002-05-10)
Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, ...
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin
(Elsevier B.V., 2002-05-10)
Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, ...
Homology and Pharmacophore Modeling, High Throughput Virtual Screening and Molecular Docking Studies to Iden!fy Poten!al Inhibitors of the Two-pore-Domain Potassium Channel K2P9.1 (TASK-3)
(2017)
Two-pore domain potassium channels (K2P) give rise to leak potassium currents, which control the excitability of the
cells. The human genome contains 15 KCNK genes coding for proteins able to form K2P channels subdivided ...
Cognitive improvement of acetylcholinesterase inhibitors in schizophrenia
Background: Schizophrenia is a severe, persistent mental disorder, and a leading cause of disability worldwide. Cognitive impairments presented in schizophrenia lead to a worse prognostic, thus treatments targeted to enhance ...
Mechanisms, regulation and functions of the unfolded protein response
(Nature, 2020)
The unfolded protein response (UPR) comprises a network of signalling pathways that reprogramme transcription, translation and protein modifications to relieve the load of unfolded or misfolded proteins in the endoplasmic ...
Solution studies and structural model of the extracellular domain of the human amyloid precursor protein
(Biophysical SocietyBethesdaEUA, 2002)
High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti
(Int Union Crystallography, 2017)
Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a ...
Snake venom phospholipase A(2) inhibitors: Medicinal chemistry and therapeutic potential
(Bentham Science Publ Ltd, 2014)