Buscar
Mostrando ítems 21-30 de 452
Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntington’s Disease
(Bentham Science Publishers Ltd., 2011)
A variety of neurological diseases including Huntington’s disease (HD), Alzheimer’s disease and
Parkinson’s disease share common neuropathology, primarily featuring the presence of abnormal protein
inclusions containing ...
Converging pathways in the occurrence of endoplasmic reticulum (er) stress in Huntington's disease
(2011)
A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease and Parkinson's disease share common neuropathology, primarily featuring the presence of abnormal protein inclusions containing ...
Haplotype analysis of the CAG and CCG repeats in 21 Brazilian families with Huntington’s disease
(Nature Publishing Group, 2017)
Neuromuscular synapse degeneration without muscle function loss in the diaphragm of a murine model for Huntington's Disease
(2018-06-01)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterized by chorea, incoordination and psychiatric and behavioral symptoms. The leading cause of death in HD patients is aspiration pneumonia, ...
AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease
(2012)
Huntington's disease (HD) is caused by mutations that expand a polyglutamine region in the amino-terminal domain of Huntingtin (Htt), leading to the accumulation of intracellular inclusions and progressive neurodegeneration. ...
Clinical and Molecular Features of Late Onset Huntington Disease in a Peruvian Cohort
(IOS Press, 2015)
Background: Late onset cases of Huntington disease (HD), with onset ≥60 years, account for up to 20% of HD cases worldwide. Clinical features include mild motor dysfunction with slow progression and cognitive impairment, ...
Action-semantic and syntactic deficits in subjects at risk for Huntington's disease
(2017)
Frontostriatal networks play critical roles in grounding action semantics and syntactic skills. Indeed, their atrophy distinctively disrupts both domains, as observed in patients with Huntington's disease (HD) and Parkinson's ...
Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics
(2023)
Neurological motor disorders (NMDs) such as Parkinson's disease and Huntington's disease are characterized by the accumulation and aggregation of misfolded proteins that trigger cell death of specific neuronal populations ...
Novos alvos farmacológicos para as doenças neurodegenerativas: Esclerose Lateral Amiotrófica e Doença de Huntington
(Universidade Federal de Minas GeraisUFMG, 2015-07-03)
Neurodegenerative diseases affect millions of people worldwide. Progressive damage relating to neuronal loss have serious consequences related to the mental and physical health of thepatient. According to the World Health ...