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Genomic instability in cytologically normal urothelial cells from patients with previous urinary bladder carcinoma.
(American Association for Cancer Research (AACR), 2002-10-01)
Genomic instability in cytologically normal urothelial cells from patients with previous urinary bladder carcinoma.
(American Association for Cancer Research (AACR), 2002-10-01)
Translocation capture sequencing: A method for high throughput mapping of chromosomal rearrangements
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Chromosomal translocations require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are involved in producing leukemias, lymphomas and sarcomas. Translocations ...
Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells
(eLife Sciences Publications, 2016-10)
The levels of the cyclin-dependent kinase (CDK) inhibitor p21 are low in S phase and insufficient to inhibit CDKs. We show here that endogenous p21, instead of being residual, it is functional and necessary to preserve the ...
Variability in Estrogen-Metabolizing Genes and Their Association with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women
(HINDAWI PUBLISHING CORPORATION, 2011)
In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genes CYP17, CYP1B1, CYP1A1, and COMT and genomic instability in the peripheral blood lymphocytes of 62 BC patients ...
Estimating genomic instability mediated by Alu retroelements in breast cancer
(Sociedade Brasileira de Genética, 2009-01-01)
Alu-PCR is a relatively simple technique that can be used to investigate genomic instability in cancer. This technique allows identification of the loss, gain or amplification of gene sequences based on the analysis of ...
Detrimental effects detected in exfoliated buccal cells from anesthesiology medical residents occupationally exposed to inhalation anesthetics: An observational study
(2018-08-01)
Operating room professionals are scarcely aware of their individual occupational exposure to waste anesthetic gases (WAGs). Medical residents spend several hours per day in operating rooms and consequently experience ...
Genomic instability in Solanum tuberosum x Solanum kurtzianum interspecific hybrids
(National Research Council Canada-NRC Research Press, 2006-02-01)
The use of interspecific crosses in breeding is an important strategy in improving the genetic base of the modern cultivated potato, Solanum tuberosum L. Until now, it has normally been interspecific Solanum hybrids that ...