Buscar
Mostrando ítems 21-30 de 151
Gabapentin Administration Reduces Reactive Gliosis and Neurodegeneration after Pilocarpine-Induced Status Epilepticus
(Public Library Science, 2013-11-08)
The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period. It has been proposed that the ...
Influence of cimetidine and experimental diabetes mellitus on gabapentin pharmacokinetics in rats
(Elsevier B.V., 2017-10-20)
Impact of diabetes on gabapentin pharmacokinetics in patients with neuropathic pain
(Elsevier B.V., 2018-10-10)
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms
(2019-03-01)
Gabapentin (GAB) is eliminated unchanged in urine, and organic cation transporters (OCT2 and OCTN1) have been shown to play a role in GAB renal excretion. This prospective clinical study aimed to evaluate the genetic ...
Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations
(2020-08-01)
Gabapentin (GBP) is an organic cation mainly eliminated unchanged in urine, and active drug secretion has been suggested to contribute to its renal excretion. Our objective was to evaluate the potential drug-drug interaction ...
Population pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control
(2021-04-01)
Aims: Gabapentin (GBP) is widely used to treat neuropathic pain, including diabetic neuropathic pain. Our objective was to evaluate the role of diabetes and glycaemic control on GBP population pharmacokinetics. Methods: A ...
Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury
(2009)
anti-hyperalgesic effects of these drugs, administered either separately or in combination, were determinedusing the von Frey and acetone tests in a rat model of neuropathic pain (Bennett model). Morphine andgabapentin ...
Early Gabapentin Treatment during the Latency Period Increases Convulsive Threshold, Reduces Microglial Activation and Macrophage Infiltration in the Lithium-Pilocarpine Model of Epilepsy
(MDPI, 2017-11)
The lithium-pilocarpine model of epilepsy reproduces several features of temporal lobe epilepsy in humans, including the chronological timeline of an initial latency period followed by the development of spontaneous seizures. ...
La insulinoterapia intensificada más antineuríticos es superior a antineurítico puro en neuropatía diabética dolorosa
(Sociedad Médica de Santiago, 2006)