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Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1998-12-04)
We investigated the role of individual charged residues of the S4 region of a MaxiK channel (hSlo) in channel gating, We measured macroscopic currents induced by wild type (WT) and point mutants of hSlo in inside-out ...
Effective pore size and radius of capture for K+ ions in K-channels
(NATURE PUBLISHING GROUP, 2016-02)
Reconciling protein functional data with crystal structure is arduous because rare conformations or crystallization artifacts occur. Here we present a tool to validate the dimensions of open pore structures of potassium-selective ...
External copper inhibits the activity of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle
(2003)
We have characterized the effect of external
copper on the gating properties of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle, incorporated into artificial
bilayers. The ...
Potassium (K plus ) gradients serve as a mobile energy source in plant vascular tissues
(NATL ACAD SCIENCES, 2012)
Distinct roles of the last transmembrane domain in controlling Arabidopsis K + channel activity
(Wiley Blackwell Publishing, Inc, 2009-04)
• The family of voltage-gated potassium channels in plants presumably evolved from a common ancestor and includes both inward-rectifying (Kin) channels that allow plant cells to accumulate K+ and outward-rectifying (Kout) ...
Understanding the structural mechanism of selective blockers of pH-gated K2P channels
(2018)
Two-‐pore
domain
potassium
(K2P)
channels
underlie
the
background
K+
currents
in
mammalian
cells.
They
can
be
segregated
into
six
subfamilies
based
on
their
structure
and
functional
properties.
The
acid-‐
sensitive
TAS ...
Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains
(American Society of Biochemistry and Molecular Biology - ASBMBBethesda, 2014-01)
KirBac channels are prokaryotic homologs of mammalian inwardly rectifying potassium (Kir) channels, and recent structures of KirBac3.1 have provided important insights into the structural basis of gating in Kir channels. ...
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K + currents in adult murine atria
(American Physiological Society, 2018-05)
G protein-gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G protein α-subunits can ...
The Role of Potassium Channels in Arabidopsis thaliana Long Distance Electrical Signalling: AKT2 Modulates Tissue Excitability While GORK Shapes Action Potentials
(2018)
Fast responses to an external threat depend on the rapid transmission of signals through a plant. Action potentials (APs) are proposed as such signals. Plant APs share similarities with their animal counterparts