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Galectins as checkpoints of the immune system in cancers, their clinical relevance, and implication in clinical trials
(Molecular Diversity Preservation International, 2020-05)
Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions. Currently, 15 members of this ...
Galectin-1 as a potential cancer target
(Nature Publishing Group, 2005-12)
Galectins are a family of structurally related carbohydrate-binding proteins, which are defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition ...
Galectins in the regulation of platelet biology
(Humana Press, 2015-01)
Platelets are anucleated blood cells derived from megakaryocytes, and although they are essential for proper hemostasis, their function extends to physiologic processes such as tissue repair, wound remodeling, and antimicrobial ...
Vascular galectins: regulators of tumour progression and targets for cancer therapy
(Elsevier, 2013-08-12)
Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor ...
Galectins: regulators of acute and chronic inflammation
(Wiley, 2010-01-12)
B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with ...
Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3
(Elsevier B.V., 2006-04-01)
Annexin 1 (ANXA1), galectin-1 (Gal-1) and galectin-3 (Gal-3) proteins have been identified as important mediators that promote or inhibit leukocyte migration. The expression of these proteins was studied in human neutrophils ...
Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3
(Elsevier B.V., 2006-04-01)
Annexin 1 (ANXA1), galectin-1 (Gal-1) and galectin-3 (Gal-3) proteins have been identified as important mediators that promote or inhibit leukocyte migration. The expression of these proteins was studied in human neutrophils ...
Duodenal intraepithelial lymphocytes of children with cow milk allergy preferentially bind the glycan-binding protein galectin-3
(Biolife Sas, 2009)
A breakdown in intestinal homeostasis results in inflammatory bowel diseases including coeliac disease and allergy. Galectins, evolutionarily conserved beta-galactoside-binding proteins, can modulate immune-epithelial cell ...
A galectin-specific signature in the gut delineates Crohn's disease and ulcerative colitis from other human inflammatory intestinal disorders
(IOS Press, 2016-01)
Inflammatory bowel diseases (IBD) are chronic and relapsing inflammatory conditions of the gastrointestinal tract including Crohn’s disease (CD) and ulcerative colitis (UC). Galectins, defined by shared consensus amino ...