Artículos de revistas
Galectins in the regulation of platelet biology
Fecha
2015-01Registro en:
Romaniuk, María Albertina; Rabinovich, Gabriel Adrián; Schattner, Mirta Ana; Galectins in the regulation of platelet biology; Humana Press; Methods In Molecular Biology (clifton, N.j.); 1207; 1-2015; 269-283
978-1-4939-1396-1
1064-3745
1940-6029
CONICET Digital
CONICET
Autor
Romaniuk, María Albertina
Rabinovich, Gabriel Adrián
Schattner, Mirta Ana
Resumen
Platelets are anucleated blood cells derived from megakaryocytes, and although they are essential for proper hemostasis, their function extends to physiologic processes such as tissue repair, wound remodeling, and antimicrobial host defense, or pathologic conditions such as thrombosis, atherosclerosis, chronic inflammatory diseases, and cancer. Recently, we demonstrated that two structurally divergent members of the galectin family, galectin-1 and galectin-8, are potent platelet agonists. The emergence of galectins as soluble mediators capable of triggering platelet activation opens a new field of research that will provide further insights into the mechanisms linking inflammatory responses to thrombus formation and could expand our view of the role of platelets much beyond hemostasis to their pathophysiologic role during inflammation and cancer. The present article details the various protocols and reagents currently used in our laboratory to study the role of galectins in human platelet function.